维生素B6缺乏和塔克罗利木斯诱导的
Cihan Uysal1, Tugba Yilmaz, Merve Civan
1From the Department of Nephrology, Erciyes University Medical Faculty, Erciyes University, Kayseri, Turkey.
概括
接受脏移植的患者往往有较低的维生素B6 (pyridoxine) 水平,增加了的风险. 在这些患者中,维生素B6缺乏可能会促进塔克罗利斯诱导的震.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
背景情况:
- 塔克罗利马斯是移植后的重要免疫抑制剂.
- 震是塔克罗利木斯治疗的常见副作用.
- 维生素B6 (pyridoxine) 在塔克罗利斯诱导的震中的作用尚不清楚.
研究的目的:
- 为了研究血pyridoxine状态与移植接受者的塔克罗利斯诱导的震之间的关系.
- 为了比较移植患者的维生素B6水平,有和没有.
主要方法:
- 包括77名脏移植接受者,他们的移植功能稳定,治疗性塔克罗利斯水平稳定.
- 测量了血pyridoxal-5'-phosphate (PLP) 水平,以评估维生素B6的状态.
- 的临床评估是使用基本评级评估尺度进行的.
- 一个由20名健康志愿者组成的对照组对维生素B6状态进行了分析.
主要成果:
- 与健康志愿者相比,接受脏移植的人的血pyridoxine水平明显较低 (8.3比13.3μg/L).
- 在35%的接受者中发现维生素B6缺乏 (PLP<7.5μg/L).
- 在58.4%的接受者中观察到震,并且在维生素B6缺乏的人群中更频繁 (77.8%vs48.0%).
- 维生素B6缺乏是震存在的独立预测因素.
结论:
- 在移植受体中,血中氧素水平较低.
- 在这个人群中,维生素B6缺乏是常见的,可能会导致塔克罗利斯诱导的震.
- 补充维生素B6可能是一个潜在的策略来管理在脏移植接受者.
相关概念视频
Insufficient Sleep and Sleep Deprivation
858
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
858
Vitamins
2.4K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.4K
Mineral, Vitamin and Water Absorption
1.5K
Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
1.5K
Role of Skin in Vitamin D Synthesis
7.6K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.6K
Role of Vitamins in Maintaining Bone Health
5.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.2K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
2.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.2K


