在纤维肌痛中,代谢综合征和与代谢功能障碍相关的脂肪性肝病
Chia-Chang Chen1, Yi-Hsing Chen2, Der-Yuan Chen3
1Taichung Veterans General Hospital.
Archives of rheumatology
|January 24, 2026
概括
纤维肌痛患者表现出更高的中心脂肪和更严重的肝硬化. 纤维肌痛的疾病严重程度增加可能与较高的心血管风险相关,突出显示需要监测与代谢功能障碍相关的脂肪性肝病.
科学领域:
- 类风湿病学 类风湿病学
- 心血管医学 心血管医学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 纤维肌痛 (FM) 是一种慢性疼痛疾病.
- 在FM患者中怀疑心血管风险增加.
- 在FM中调查心血管风险因素至关重要.
研究的目的:
- 评估纤维肌痛患者心血管风险因素.
- 为了比较传统的风险因素,FM患者和对照者之间的动脉内膜介质厚度 (IMT) 和代谢综合征.
- 评估FM中代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率和严重程度.
主要方法:
- 预期招募初级 FM 患者和健康对照组.
- 评估传统的心血管风险因素,动脉IMT和代谢综合征.
- 通过超声波测定MASLD和肝硬化症的严重程度 (Saverymuttu和Hamaguchi分数).
- 使用多变量逻辑和线性回归分析.
主要成果:
- 与对照组相比,纤维肌痛患者表现出明显更高的中心脂肪度 (OR 6.1).
- FM患者呈现出更严重的肝肥胖症,特别是哈马古奇评分.
- 女性 FM 患者患有 MASLD 的患病率更高 (OR 2.8).
- 在FM的疾病严重程度与左侧IMT和脂质水平相关.
结论:
- 纤维肌痛与增加的中央脂肪和更严重的肝硬化症有关.
- 更高的心血管风险可能与严重的FM症状有关.
- 与代谢功能障碍相关的脂肪性肝病需要在纤维肌痛管理中更加注意.
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