纤维化-4分数和代谢功能障碍相关的脂肪性肝病的术后结果
Fatih Eren1, Mehmet Refik Goktug1, Derya Ari2
1Department of Gastroenterology, Bursa Uludağ University School of Medicine, Bursa, Türkiye.
纤维化-4 (FIB-4) 评分可以预测代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的术后并发症. 高FIB-4分数表明手术患者患有MASLD的风险增加.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 手术风险评估手术风险评估
- 非侵入性的生物标志物
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 的患病率在全球范围内正在上升.
- 纤维化-4 (FIB-4) 评分是评估晚期肝纤维化的非侵入性工具.
- 预测MASLD患者的手术结果至关重要.
研究的目的:
- 调查FIB-4得分对术后并发症的预测价值.
- 评估MASLD手术患者的FIB-4分数和死亡率之间的关联.
主要方法:
- 一项多中心的回顾性研究包括了11 072名接受手术的患者.
- 分析的数据包括人口统计,并发症,FIB-4分数和手术结果.
- 倾向性得分匹配用于高FIB-4得分的患者.
主要成果:
- 分析了1667名MASLD患者,根据FIB-4分数进行分类.
- 高FIB-4得分与术后并发症的增加显著相关 (P < .001).
- 在高FIB-4得分的患者中观察到12个月死亡率上升的趋势,尽管在统计学上不显著 (P = .481).
结论:
- 高FIB-4分数可以作为MASLD患者术后并发症的预测标记.
- 在MASLD患者的手术风险分层中,FIB-4得分的有用性需要进一步研究.
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