多重系统缩中的疼痛类型
Nicole Campese1,2, Mubasher A Qamar3, Maria Alexandra Chiriac3,4
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
概括
多系统缩 (MSA) 与频繁的夜间,肌肉骨和波动相关的疼痛有关. 了解这些疼痛类型对于开发针对MSA患者的向治疗至关重要.
科学领域:
- 神经学 神经学
- 疼痛医学 医学 疼痛医学
- 临床研究 临床研究
背景情况:
- 疼痛是多系统性缩症 (MSA) 的普遍和沉重的症状,影响到87%的个体.
- 导致MSA总体负担的疼痛的具体类型和患病率仍然不完全理解.
研究的目的:
- 确定多系统性缩 (MSA) 患者体验的各种疼痛类型的频率.
- 为了比较MSA的疼痛患病率与帕金森病 (PD) 和健康对照.
主要方法:
- 在2023年,对患有MSA的个人进行了一项基于网络的调查,使用国王帕金森病疼痛问卷 (KPPQ) 和其他MSA特定的疼痛问题.
- 受访者年龄,性别和疾病持续时间与PD患者和健康对照者的历史队列相匹配 (n=96个).
主要成果:
- 夜间疼痛 (73%),肌肉骨疼痛 (63%) 和与波动相关的疼痛 (62%) 是MSA中最常见的KPPQ报告的疼痛.
- 与健康对照组相比,MSA患者报告大多数KPPQ疼痛类型的频率较高,肌肉骨疼痛除外.
- 与PD患者相比,MSA患者的肌肉骨疼痛较少,但面部疼痛较多.
结论:
- 多系统性缩 (MSA) 与多种类型的疼痛有关,包括非特异性和与疾病相关的疼痛,这些疼痛可能是神经病变性,感觉性或鼻膜性.
- 在MSA中识别不同的疼痛来源对于开发个性化治疗策略至关重要.
- 建议针对运动和非运动症状的向治疗用于MSA的综合性疼痛管理.
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