剩余胆固醇/高密度脂蛋白胆固醇的比率是一个新的强大工具,用于识别糖尿病病
Jiale Zhang1, Shuping Zhou2, Haojie Zhang1
1Department of Nephrology, The Affiliated Lihuili Hospital of Ningbo University, Ningbo City, China.
Journal of diabetes investigation
|January 24, 2026
概括
剩余胆固醇与高密度脂蛋白胆固醇 (RHR) 的比率与2型糖尿病患者糖尿病病 (DKD) 风险增加有关. 较高的RHR水平与较高的DKD患病率相关,这表明它可以作为预测生物标志物.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
背景情况:
- 剩余胆固醇与高密度脂蛋白胆固醇的比率 (RHR) 是已知的代谢疾病的预测因素.
- 在2型糖尿病 (T2DM) 患者中,RHR和糖尿病病 (DKD) 之间的关联尚未得到充分理解.
- DKD是T2DM的一个严重并发症,需要可靠的风险评估工具.
研究的目的:
- 调查RHR与T2DM患者的DKD风险之间的关联.
- 探索RHR作为DKD风险分层的生物标志物的潜力.
主要方法:
- 一项涉及2,958名在2018年至2023年期间住院的T2DM患者的横截面研究.
- 使用限制立方线 (RCS) 和逻辑回归进行分析,并进行分层和相互作用分析.
- 使用曲线下的面积 (AUC) 与其他脂质参数相比,评估RHR的预测性能.
主要成果:
- 随着RHR的四分位数较高 (39.6%至60.7%),DKD的患病率增加.
- 后勤回归显示RHR和DKD (OR=1.14) 之间存在正相关性,特别是在60岁以上的患者中.
- RCS发现了一个反转的L形关联,其拐点为RHR=1.31;SBP和FPG是部分调解者.
结论:
- 在T2DM患者中,RHR与DKD的风险有关.
- RHR显示出作为一种具有成本效益的生物标志物的潜力,用于识别患有DKD高风险的个体.
- 进一步的研究可能会验证RHR在DKD风险评估中的常规临床使用.
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