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Updated: Jan 25, 2026

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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
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血糖控制不良和顶端牙周炎之间的关联:系统性审查和元分析
1Chongqing Dental Hospital No. 345 Minsheng Road, Yuzhong District Chongqing 400010, China laij0122@163.com.
Medicina oral, patologia oral y cirugia bucal
|January 24, 2026
概括
糖尿病血糖控制不良 (PGC) 显著增加了牙周炎 (AP) 的风险,并阻碍了愈合. 管理PGC对于改善内牙治疗结果和口腔健康至关重要.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 糖尿病 (DM) 通过免疫和炎症途径与口腔健康受损有关.
- 持续的高血糖可能会影响牙周炎 (AP) 的发病和愈合.
研究的目的:
- 系统地审查和元分析血糖控制不良 (PGC) 和顶端牙周炎 (AP) 之间的关联.
- 为了评估PGC对AP流行率和内牙治疗中愈合的影响.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 在PubMed,Embase,Google Scholar和Scopus中搜索到2025年6月之前的英语语言研究.
- 包括对HbA1c水平和AP结果的横截面和纵向研究;使用RevMan 5.3.3合成的数据.
主要成果:
- 18项研究 (51,070名患者) 分析了PGC与AP患病率,根充满牙中的AP (AP-RFT) 和免疫反应的关系.
- 患有PGC的人患AP (OR=2.38) 和AP-RFT持久性 (OR=2.74) 的风险明显更高.
- 研究报告称,PGC患者的炎症性细胞因子和细菌负载升高.
结论:
- PGC会对AP的发育和愈合产生负面影响,可能是通过免疫-炎症通路.
- PGC与内牙治疗后的AP发生和未成功的周围牙愈合有关.
- 个人化DM管理被推为内牙患者,以提高结果.
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