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生物启发的多功能水凝用于深度学习启用的伤口pH视觉监测和治疗
Tuohao Jiang1,2, Xinglai Tong2, Shuxin Shi1
1Department of Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Analytical chemistry
|January 24, 2026
概括
这项研究介绍了一种智能水凝敷料,可以监测伤口的pH值并抵抗感染. 生物灵感的EVQ水凝促进了难以愈合的伤口的快速愈合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 伤口愈合技术 伤口愈合技术
背景情况:
- 难以治愈的伤口的有效管理需要具有实时监测和治疗能力的先进带.
- 目前的伤口护理往往缺乏环境感知和有针对性的干预的综合解决方案.
- 智能伤口包裹代表了改善患者治疗结果和减少医疗保健负担的有希望的前沿.
研究的目的:
- 开发一种多功能,生物灵感的水凝 (EVQ),用于智能伤口愈合.
- 将响应pH的视觉监测,广泛的抗微生物活性和机械适应性整合到一个单一的伤口包裹中.
- 在体外和临床前伤口模型中评估水凝的性能.
主要方法:
- 用葡萄糖氧化酶 (GOx) - 黑用于快速凝的酶级联启动的现场氧化还原聚合.
- 加入四分化酸盐 (QCS) 来增强机械性能和粘附性.
- 整合红色用于视觉pH值监测,并开发一个深度学习模型 (ResNet34) 用于pH值分类.
- 在体外对大肠杆菌和黄金杆菌的抗菌分析,以及使用L929细胞的细胞毒性测试.
- 在感染 Staphylococcus aureus 的小鼠伤口模型中的体内评估,评估伤口关闭,原沉积和炎症标志物.
主要成果:
- EVQ水凝表现出快速的in situ凝 (∼30秒),可注射性,以及优良的机械性能 (抗拉强度增加60%),具有强大的粘附性.
- 包裹表现出广泛的抗菌活性 (>90%的抑制) 和良好的细胞相容性 (L929细胞活力>80%).
- 红色的整合允许通过深度学习模型进行视觉pH监测 (pH5-9),在pH分类中达到93.25%的准确性.
- 活体研究显示,伤口关闭加速 (到第12天残留面积<0.5%),组织再生标志物增强,炎症减少.
结论:
- 生物灵感EVQ水凝是一种用于智能伤口管理的多功能平台.
- 它有效地结合了快速自我愈合,抗微生物特性,机械适应性和先进的pH感应能力.
- EVQ水凝显示出下一代伤口护理的巨大潜力,促进加速愈合和改善临床结果.
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