基于Pyrene的聚合诱导的排放性碳化合物复合物用于绿色光控制的一氧化碳 (CO) 释放和治疗应用
Vinod Kumar1, Kanika2, Rimpi Devi1
1Department of Chemistry, National Institute of Technology Kurukshetra, Kurukshetra, Haryana 136119, India.
Inorganic chemistry
|January 24, 2026
概括
一种基于的新型一氧化碳释放分子 (CORM),Py-CO,提供光激活治疗和成像. 这种双重功能平台通过释放一氧化碳 (CO) 并实现实时生物成像,证明了潜在的抗癌疗效.
科学领域:
- 材料科学 材料科学 材料科学
- 化学 化学 化学
- 生物医学工程 生物医学工程
背景情况:
- 一氧化碳 (CO) 已被认为具有治疗潜力.
- 一氧化碳释放分子 (CORM) 能够控制CO的输送.
- 开发具有高级功能的新型CORM对于theranostics至关重要.
研究的目的:
- 引入一种新的基于的CORM,Py-CO,其中包含一个pyrene fluorophore.
- 调查Py-CO对光触发的CO释放和聚合诱导排放 (AIE) 的双重功能.
- 评估Py-CO在癌症治疗和成像中的体外治疗潜力.
主要方法:
- 合成基于的CORM,Py-CO,用一个烯化物.
- 使用SEM,光寿命,DLS和计算研究对Py-CO聚合的表征.
- 在体外评估CO释放动力学,SH-SY5Y细胞中的细胞毒性,细胞吸收和生物成像.
主要成果:
- Py-CO 显示绿灯触发的 CO 释放和聚合诱导的排放 (AIE).
- 与非聚合状态相比,聚合的Py-CO显示了增强的CO释放动态.
- Py-CO诱导神经母细胞瘤细胞的细胞死亡,显示出抗癌疗效,并使同时进行成像和治疗.
结论:
- Py-CO是一种新的,光激活的,AIE活性的CORM,具有双重治疗和成像能力.
- 该平台有助于高效的二氧化碳释放和实时监测潜在的癌症治疗.
- 在开发用于综合诊断和治疗的多功能药物方面,Py-CO是一个有前途的进步.
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