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相关概念视频

Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility02:34

Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility

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Intermolecular forces are attractive forces that exist between molecules. They dictate several bulk properties, such as melting points, boiling points, and solubilities (miscibilities) of substances. Molar mass, molecular shape, and polarity affect the strength of different intermolecular forces, which influence the magnitude of physical properties across a family of molecules.
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
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NMR Spectroscopy Of Amines01:19

NMR Spectroscopy Of Amines

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In proton NMR spectroscopy, primary amines and secondary amines showcase their N–H protons as a broad signal in the chemical shift range between δ 0.5 and 5 ppm. The exact position in this range depends on several factors, including sample concentration, hydrogen bonding, and the type of solvent used. Since amine protons undergo fast proton exchange in solution, the protons are labile and therefore do not participate in any splitting with adjacent protons. Thus, the observed peak is...
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Molecular and Ionic Solids02:54

Molecular and Ionic Solids

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Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
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NMR Spectroscopy of Aromatic Compounds01:14

NMR Spectroscopy of Aromatic Compounds

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Aromatic compounds can be identified or analyzed using proton NMR and carbon‐13 NMR. Typically, aromatic hydrogens or hydrogens directly bonded to the aromatic rings are strongly deshielded by the aromatic ring current. Therefore, they absorb in the range of 6.5–8.0 ppm in proton NMR spectra. For instance, aromatic hydrogens directly bonded to the benzene ring absorb at 7.3 ppm. However, aromatic hydrogens of larger rings absorb farther upfield or downfield than the ideal range.
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NMR Spectroscopy of Benzene Derivatives01:34

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Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling...
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Structures of Solids02:22

Structures of Solids

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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Preparation of Fungal and Plant Materials for Structural Elucidation Using Dynamic Nuclear Polarization Solid-State NMR
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使用风湿学和固态NMR光谱学探测喷雾干燥和融化的无形分散物的可混合性.

Sichen Song1,2, Tianyun Zhang3, Jianchao Xu3

  • 1Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Molecular pharmaceutics
|January 24, 2026
PubMed
概括

一种新的风湿学方法有效地估计了混合性,并预测了赛莱科西布 (CEL) 和聚烯立 (PVP) 在无形固体分散 (ASD) 中的结晶. 这种方法有助于设计稳定的ASD配方,以改善药物存储.

关键词:
无形固体分散的无形固体分散结晶化 结晶化的过程.融灭器可以灭融.混杂性 混杂性 混杂性度重叠是因为度重叠.物理稳定性 物理稳定性类风病学 类风病学 类风病学固态NMR是一种固态NMR.喷雾干燥 喷雾干燥

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科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学
  • 固态化学 固态化学

背景情况:

  • 无形固体分散 (ASDs) 提高了药物的溶解性和生物可用性.
  • 在ASD中控制药物结晶对于长期稳定至关重要.
  • 评估ASD的混合性和结晶倾向对于配方开发至关重要.

研究的目的:

  • 评估一种c*指导的高温风湿学方法,用于估计赛莱可西布 (CEL) /聚烯利 (PVP) ASD 的混合性.
  • 通过灭和喷雾干燥制备的ASD的混合性和结晶行为进行比较.
  • 为了验证与固态核磁共振 (ssNMR) 测量对抗的风学方法.

主要方法:

  • 使用灭和喷雾干燥技术制备CEL/PVP ASD.
  • 以临界聚合物度 (c*) 为指导的高温风湿学测量.
  • 固态核磁共振 (ssNMR) 1H T1ρ和1H T1放松时间测量和旋转扩散研究.

主要成果:

  • 在估计ASD混合性时,rheological方法和ssNMR之间发现了一般一致性.
  • 风学方法适用于现有ASD粉末,与可以删除处理历史的ssNMR不同.
  • 当聚合物度超过c* (c > c*) 时,结晶趋势显著降低,从而延迟了药物结晶.
  • 当c < c*时,结晶的开始类似于整洁的无形CEL.

结论:

  • 以c*为指导的风学方法是一种高效的,节约材料的方法,用于评估ASD的混合性和预测结晶稳定性.
  • 这种方法适用于融挤压和喷雾干燥的ASD.
  • 这些发现支持了强大的ASD的合理设计,并提高了长期存储的稳定性.