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在 gentamicin 诱导的毒性中,性别依赖的转录反应和可药物标

Pınar Portakal¹, Tuğba Gürkök-Tan²

¹Food and Agriculture Vocational School, Cankiri Karatekin University, Çankırı, Turkey. pinarportakal@karatekin.edu.tr.

Naunyn-Schmiedeberg's archives of pharmacology

|January 24, 2026

概括

在雄性和雌性大鼠中,甘他因损伤的原因不同. 共享的细胞循环基因参与其中,但在恢复过程中出现性别特定的修复途径,这表明可能需要量身定制的治疗方法.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
基因组学就是基因组学.
药理学药理学是指药理学的学科.

背景情况:

胺是一种具有已知的毒性抗生素,限制了其临床使用.
人们怀疑损伤和 gentamicin 恢复的性别特异性差异,但在分子层面上了解得很少.

研究的目的:

为了研究 gentamicin 诱导的损伤和恢复中的性别特异性转录特征.
确定关键的基因,转录因子和参与这些性别特异反应的可药物途径.

主要方法:

在受伤 (15日) 和恢复 (29日) 的时间点对大鼠脏组织的RNA测序.
不同基因表达分析,功能丰富 (GO/KEGG),枢纽基因和转录因子检测.
使用DGIdb的药物基因相互作用查.

主要成果:

男性表现出更广泛的转录反应;女性表现出更狭窄,更明显的模式.
在两性中都发现了细胞循环基因 (BIRC5,BUB1B,CCNA2,CDC20) 的共同核心.
出现了性别特定的恢复途径:女性的CCNB1,PBK,NUF2;男性的CDCA8. 在受伤期间,DNMT1是男性偏差的.
在性别特定的枢纽中,只有CCNB1具有可药物相互作用;核心细胞循环基因具有高度可药性.

结论:

甘胺的毒性涉及一个由性别特异性修复机制调节的共同细胞循环核心.
这些发现为开发针对性别的治疗策略提供了分子基础,以应对 جنت米辛诱导的损伤.

关键词:

药物基因相互作用甘胺氨酸脏毒性甘胺氨酸脏毒性枢纽基因枢纽基因枢纽基因网络分析网络分析性差异性差异性差异性差异性差异性差异性差异性文字转录学 (Transcriptomics) 是一个学科.

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