COVID-19疫苗接种和短期死亡风险:荷兰全国自控病例系列研究
Isabel A L Slurink1, Annemarijn R de Boer2, Marc J M Bonten2,3
1Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands. I.A.L.Slurink@umcutrecht.nl.
European journal of epidemiology
|January 24, 2026
概括
接种COVID-19疫苗与所有原因死亡率的显著降低有关,在接种疫苗后观察到的发病率降低了44%. 这一发现支持疫苗接种不会导致大流行期间的过度死亡率.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在COVID-19大流行期间的过度死亡率超过了COVID-19导致的死亡率,这表明其他因素也有所贡献.
- 了解像疫苗接种这样的干预措施对整体死亡率的影响至关重要.
研究的目的:
- 调查COVID-19疫苗接种与荷兰人口过度死亡率之间的关联.
- 为了确定COVID-19疫苗接种是否有助于或减轻过度死亡率.
主要方法:
- 所有荷兰居民的回顾性数据链接研究.
- 修改自控病例系列方法来分析死亡风险.
- 在接种疫苗/感染之前和之后的时间段中,所有原因的死亡率的比较.
主要成果:
- 在初级COVID-19疫苗接种三周内,观察到所有原因死亡的相对发病率降低了44% (IRR为0.56).
- 这种保护作用在各种人口统计,疫苗类型和健康状况中是一致的.
- 补充接种疫苗显示死亡风险降低类似 (IRR为0.49).
- 相比之下,SARS-CoV-2感染显示所有死因的发病率增加了16倍 (IRR 16.19).
结论:
- 在接种COVID-19疫苗后,短期死亡风险明显降低.
- 接种COVID-19疫苗与大流行期间观察到的过度死亡率无关.
- 疫苗似乎减轻了,而不是导致过度死亡率.
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