弗莱什纳定义的间歇性肺异常中的多种组织病理学模式:使用2025年美国胸腔学会声明的放射学-病理学相关性和重新分类.
Taiki Fukuda1, Kaori Ishida2, Tomonori Tanaka3
1Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA; Department of Radiology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Respiratory investigation
|January 24, 2026
概括
间歇性肺异常 (ILA) 通常代表早期间歇性肺病 (ILD). 这项研究发现,到2025年ATS标准,大多数Fleischner定义的ILA病例被重新归类为亚临床ILD,揭示了除通常的间歇性肺炎 (UIP) 外的多样化组织病理.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 病理学 病理学 病理学
背景情况:
- 间歇性肺异常 (ILA) 是CT检测到的发现,可能表明早期间歇性肺病 (ILD).
- 与ILA和ILD相关的组织病理学数据有限,之前的研究产生了相互矛盾的结果.
- 美国胸腔协会 (ATS) 的2025年标准旨在区分ILA和ILD.
研究的目的:
- 检查弗莱什纳学会定义的ILA的组织病理学谱.
- 为了将组织病理学发现与CT特征和患者结果相关联.
- 根据2025年ATS标准重新分类ILA案件.
主要方法:
- 对30名ILA手术肺活检患者 (2010-2021) 的回顾性分析.
- 由三个肺病理学家进行的组织病理学评估和由两个放射学家进行的CT评估.
- 与常见间歇性肺炎 (UIP) 相关的和与UIP无关的组之间的总生存率的比较.
主要成果:
- 大多数患者 (90%) 患有纤维性ILA,主要根据2025年ATS标准重新分类为亚临床ILD (96.7%).
- 常见间歇性肺炎 (UIP) 是最常见的主导模式 (43.3%),其次是非特异性间歇性肺炎 (NSIP) 和支气管中心间歇性肺炎 (BIP) (20%).
- CT发现包括UIP/NSIP的网状不透明度和引支气管切除,以及BIP的分支线性不透明度. 在与UIP相关的和与UIP无关的组之间没有观察到总生存时间的显著差异.
结论:
- 根据Fleischner定义的ILA,当根据2025年ATS标准重新分类时,往往是亚临床ILD.
- ILA的组织病理学是异质的,超越UIP,包括像BIP这样的模式.
- 这些发现强调了在了解ILA及其向ILD的进展方面,组织病理学多样性的重要性.
相关概念视频
Correlations
35.8K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
Abnormal Proliferation
5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Correlation and Causation
42.4K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.4K
Thoracic Aorta
1.6K
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
1.6K
Radiological Investigation I: X-ray and CT
1.1K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.1K
The Thoracic Cage: Sternum
5.9K
The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
5.9K


