基托奥利高糖化物修饰的费里丁核心载体增强了素的稳定性和缓释性能
Xiaoyue Liang1, Zhikun Xing1, Chen Chen1
1Key Laboratory of Characteristics Agricultural Product Processing and Quality Control (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, School of Food Science and Technology, Shihezi University, Shihezi, Xinjiang 832000, China; Key Laboratory for Food Nutrition and Safety Control of Xinjiang Production and Construction Corps, School of Food Science and Technology, Shihezi University, Shihezi, Xinjiang 832000, China; School of Food Science and Technology, Shihezi University, Shihezi, Xinjiang 832000, China.
研究人员创建了一个新的纳米颗粒输送系统,使用鱼类费里来增强 rutin 的稳定性和吸收性. 这种基托奥利高糖化物-阿波费里丁-鲁 (COS-Apo-Rutin) 系统可以改善多的输送,从而获得更好的健康益处.
科学领域:
- 生物材料科学 生物材料科学
- 营养科学 营养科学
- 纳米技术纳米技术
背景情况:
- 像鲁丁这样的多提供健康益处,但稳定性和生物可用性不佳.
- 费里丁是一种天然的蛋白质外,显示出缩生物活性化合物的潜力.
- 北方肝费里 (NPLF) 为新型输送系统提供了一个pH响应的平台.
研究的目的:
- 开发一个核心外纳米粒子系统,以改善常规交付.
- 使用NPLF和Citooligosaccharide (COS) 来增强 rutin 稳定性和控制释放.
- 评估该新系统的物理化学性质,抗氧化活性和体外消化阻力.
主要方法:
- 通过静电吸附合成核心外纳米粒子 (COS-Apo-Rutin).
- 使用动态光散射和传输电子显微镜 (TEM) 进行粒子形态和大小的表征.
- 评估封装效率,热稳定性,抗氧化活性 (DPPH测定) 和体外模拟消化.
主要成果:
- 成功合成了具有纳米尺度直径的球形COS-Apo-Rutin纳米粒子.
- 实现了18.4%的封装效率和更好的热稳定性 (+4.38°C).
- 已证明其抗氧化活性有所降低,顺序为:自由鲁 > 阿波鲁 > COS-阿波鲁,具有对素和素消化增强的抵抗力.
结论:
- 该COS-Apo-Rutin核心外系统有效地提高了rutin稳定性和交付性能.
- 这种纳米粒子系统显示了鱼类副产品的改进利用和有针对性的营养物质输送的潜力.
- 基于pH响应的NPLF系统提供了一种有前途的策略,用于输送像rutin这样的生物活性化合物.
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