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相关概念视频

Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Infertility in Females01:28

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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相关实验视频

Updated: Jan 26, 2026

Murine Fecal Isolation and Microbiota Transplantation
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不孕症和微生物群

Lingying Zhang1, Ting Wang2, Na Zhu2

  • 1Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science & Technology, Xinjiang University, Xinjiang 830046, China; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.

Journal of reproductive immunology
|January 24, 2026
PubMed
概括
此摘要是机器生成的。

生殖道和肠道中的微生物失衡与不孕症有关. 了解这些肠道和生殖道微生物群可以导致治疗不孕症的新诊断和治疗策略.

关键词:
不孕不育 不孕不育 不孕不育与不孕症相关的生殖障碍微生物群中的微生物群生殖系统的繁殖系统.

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科学领域:

  • 微生物学 微生物学
  • 生殖医学 生殖医学
  • 免疫学 免疫学 免疫学

背景情况:

  • 人体拥有大量对健康至关重要的微生物.
  • 不孕症是一个主要的公共卫生问题,影响着夫妇的幸福.
  • 生殖道微生物群 (阴道,子宫,子宫,丸) 对于怀孕至关重要.

研究的目的:

  • 审查将微生物群失生症与不孕症联系在一起的机制.
  • 探索微生物群的诊断,预后和治疗潜力.
  • 分析用于不孕症治疗的微生物向策略.

主要方法:

  • 文献综述侧重于生殖和肠道微生物群.
  • 机制的分析:失调,免疫失衡,炎症,信号通路.
  • 检查性别特定的微生物群角色.

主要成果:

  • 生殖道和肠道微生物群的失生有助于不孕.
  • 机制包括改变的细菌比率,免疫功能障碍和炎症.
  • 性别特定的微生物群提供了诊断和治疗潜力.

结论:

  • 微生物群失生症是不孕症的一个重要因素.
  • 向微生物群为不孕症治疗提供了一个有希望的途径.
  • 未来的研究可以为精准医学对不孕症的方法铺平道路.