斑马鱼的Pyraclostrobin诱导的生殖和代际发育毒性:微塑料的调节作用
Zhihong Chen1, Chaofan Ma1, Yang Wang1
1Inner Mongolia Key Laboratory of Environmental Pollution Control & Waste Resource Reuse, School of Ecology and Environment, Inner Mongolia University, Hohhot 010021, China.
Journal of hazardous materials
|January 24, 2026
概括
杀菌剂Pyraclostrobin (PYR) 伤害了斑马鱼的繁殖和后代. 与微塑料同时暴露会改变PYR积累,但有时会减少毒性作用,突出显示复杂的生态风险.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 水生毒理学 水生毒理学
背景情况:
- 昆外部抑制剂 (QoI) 杀菌剂,如Pyraclostrobin (PYR) 在农业中至关重要,但具有生态风险.
- PYR和微塑料 (MP) 对水生生物的联合毒性影响尚不清楚.
研究的目的:
- 调查斑马鱼中PYR的生殖和代际毒性.
- 评估聚乙烯微塑料 (PE-MPs) 对PYR生物积累和毒性的影响.
- 评估PYR和PE-MPs对斑马鱼繁殖和后代的相互作用影响.
主要方法:
- 成年斑马鱼 (Danio rerio) 单独接触PYR,并与PE-MPs结合使用.
- 分析了PYR的组织特异性生物积累.
- 评估了生殖表现,代际健康和基因表达.
- 研究对比了老年PE-MP和未使用的PE-MP.
主要成果:
- 在特定的斑马鱼组织中积累的PYR,主要是肠道和肝脏.
- PE-MPs改变了PYR分布,增加了肠道和结积累,同时降低了肝脏,大脑和淋巴细胞水平.
- 无论是PYR还是PYR+PE-MP,都会影响生殖能力和代际健康.
- 联合暴露有时会减轻PYR的毒性作用,老年议员比初生的议员造成的干扰较少.
结论:
- 皮拉克洛斯特罗宾对水生生物构成繁殖和代际风险.
- 微塑料可以改变真菌杀菌剂的生物积累和毒性,老年MP显示效果减弱.
- 这项研究为杀菌剂和微塑料共同污染的生态风险评估提供了关键数据.
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