额头白质超强度负担预测了对N-乙半氨酸和在血管轻度认知障碍中的运动的认知反应
Ethan Mah1, Damien Gallagher2, Fuqiang Gao3
1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada; Department of Pharmacology & Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Neurobiology of aging
|January 24, 2026
概括
血管轻度认知障碍 (vaMCI) 患者通过运动改善了执行功能 (EF). 较低的前额白质过强度 (WMH) 预测了与N-乙半氨酸 (NAC) 治疗3个月后更好的TMT-B性能.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 血管轻度认知障碍 (vaMCI) 是痴呆症的前体,其特点是脑血管疾病引起的认知缺陷.
- 白质高强度 (WMH) 量增加与vaMCI中的执行功能 (EF) 降低有关.
- 了解影响EF改进的因素对于开发有针对性的vaMCI干预措施至关重要.
研究的目的:
- 调查基线前额和全球WMH体积是否预测vaMCI患者接受N-乙半氨酸 (NAC) 和运动治疗的EF改善.
- 为了比较NAC加运动与安慰剂加运动对EF结果的影响.
- 探索WMH负担,治疗和时间对认知表现的相互作用.
主要方法:
- 58名vaMCI参与者接受了运动治疗,并随机分配到NAC或安慰剂.
- 执行功能使用Trail Making Test Part B (TMT-B),数字符号编码测试 (DSCT) 和基线,3个月和6个月的语音流性进行评估.
- 白质超强度 (WMH) 量从基线MRI扫描量化,并使用线性混合模型进行分析.
主要成果:
- 所有参与者在6个月的时间里,在TMT-B和语音流性方面都出现了显著的改善.
- 与安慰剂相比,一个显著的相互作用表明基线较低的额头WMH体积预测了NAC组3个月后在TMT-B中较大的改善.
- 对于DSCT或语音流性没有观察到任何显著的相互作用,全球WMH也没有预测治疗反应.
结论:
- vaMCI患者在运动时表现出EF改善,不论是NAC治疗或WMH体积.
- 基线额头WMH体积可以确定短期内从特定EF任务中从NAC治疗中获益更多的个体.
- 在vaMCI临床试验中,重要的是要考虑参与者的异质性,特别是WMH负担.
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