炎症与癌症幸存者心血管死亡风险之间的关联
Quan Yang1, Jiazhen Zheng2, Chunting Zhao1
1Cardiac and Vascular Center, Division of Cardiovascular Medicine, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China; Shenzhen Clinical Research Center for Rare Diseases, Shenzhen, China.
JACC. Advances
|January 24, 2026
概括
慢性炎症,由高C反应蛋白 (CRP) 水平表明,显著增加了癌症幸存者的心血管死亡风险. 向炎症可能会减少心脏病死亡人数.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 炎症研究 炎症研究
背景情况:
- 癌症和心血管疾病 (CVD) 共享高死亡率和疾病负担.
- 炎症是癌症和心血管疾病的常见风险因素.
- 关于系统性炎症对癌症幸存者的心血管疾病死亡率的影响的数据有限.
研究的目的:
- 研究癌症幸存者的炎症和心血管死亡率之间的关联.
- 确定高C反应蛋白 (CRP) 水平是否预测该人群中心血管疾病死亡率.
主要方法:
- 分析了15,420名英国生物库参与者,他们有癌症史,没有积极治疗.
- 利用多变量竞争风险模型来评估CRP水平和心血管疾病死亡风险.
- 根据社会人口统计学,生活方式和临床因素进行调整.
主要成果:
- 在未经调整的分析中,高CRP水平 (>2 mg/L) 与心血管死亡风险增加1.12倍有关.
- 在多变量调整后,CRP水平>2 mg/L仍然与64%的心血管死亡风险增加显著相关 (sHR: 1.64; P = 0.023).
- 小组分析证实了这些一致的发现.
结论:
- 慢性炎症与癌症幸存者的心血管死亡率增加显著相关.
- 研究结果表明,在癌症幸存者中降低心血管疾病死亡率是潜在的治疗目标.
- 需要进一步的研究来探索针对炎症途径的干预措施.
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