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Updated: Jan 26, 2026

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比索普罗洛尔用于预防COPD的不良心脏事件 (PACE):多中心,双盲,随机,受控,第三阶段试验
Christine R Jenkins1, Allison Martin1, Catherina L Chang2
1The George Institute for Global Health and University of New South Wales, Sydney, NSW, Australia.
The Lancet. Respiratory medicine
|January 24, 2026
概括
在患有慢性阻塞性肺病 (COPD) 的患者中,比索普罗罗罗尔没有改善心脏呼吸系统健康. 这项研究发现,双醇和安慰剂组之间的死亡率,住院或恶化情况没有显著差异.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 临床试验 临床试验
背景情况:
- 心血管疾病在COPD患者中很普遍,但β-阻断剂的疗效仍然不确定.
- 这项研究研究了比索醇对COPD心肺呼吸系统结果的影响.
- 资金由澳大利亚国家卫生和医学研究委员会和新西兰卫生研究委员会提供.
研究的目的:
- 评估比索普罗罗罗尔是否能改善常规护理的COPD患者的心肺呼吸状况.
- 为了评估 bisoprolol 在这个人群中的安全性和有效性.
主要方法:
- 一个双盲,随机,受控的第三阶段试验,涉及22个地点的280名参与者.
- 参与者每天接受双醇 (1.25-5毫克) 或安慰剂,持续2年.
- 主要结局是心肺呼吸系统事件的组合,使用意图对待方法分析,具有胜利比率.
主要成果:
- 与安慰剂相比,比索普罗罗罗尔在复合心肺呼吸结果中没有显著差异 (胜率为0.95,p=0.72).
- 在所有原因死亡率,心肺呼吸系统住院,主要心脏不良事件或COPD恶化方面没有发现显著差异.
- 不良事件,包括COPD恶化和死亡,在各组之间是相似的,不归因于治疗.
结论:
- 在中度重症慢性肺炎患者中,比索普罗治疗并没有改善整体心肺呼吸系统健康.
- 该研究发现,双醇对死亡率或严重心肺呼吸系统事件没有显著影响.
- 在这组患者中,比索醇与不良事件的增加无关.
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