附肌肉质量和肉症对人类健康的全面评估:来自NHANES计划的证据
Xiao Long1, Ruizhi Chen1, Yanmin Lu1
1Department of Orthopedic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Experimental gerontology
|January 24, 2026
概括
高附肌肉量 (ALM) 与更好的健康结果和较低的死亡风险有关. 低肌肉质量 (sarcopenia) 与疾病风险和死亡率的增加有关.
科学领域:
- 老年学是一门学科.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 关于肌肉质量的全身影响的临床和流行病学数据有限.
- 肌肉功能对整体健康至关重要,但其更广泛的影响需要进一步研究.
研究的目的:
- 调查尾肌肉质量 (ALM) 和肉与各种健康结果之间的关联.
- 通过使用NHANES数据,提供关于肌肉质量的系统性影响的新流行病学证据.
主要方法:
- 利用了来自11个国家健康和营养检查调查 (NHANES) 周期 (1999-2020) 的数据.
- 包括来自国家死亡指数 (NDI) 的死亡率数据和来自问卷的疾病状况.
- 用多重回归,平滑曲线拟合和值效应模型进行关联分析.
主要成果:
- 尾肌瘦质量 (ALM) 显示了与高尿血和恶性瘤的L形关系.
- ALM与喘,COPD,RA,结石病,抑郁症和癌症死亡率相反相关.
- ALM证明了对骨关节炎,全因死亡率和心血管死亡率的保护作用; 石病与骨质疏松症的反向关联以及与COPD,喘,OA,抑郁症和全因死亡率的积极关联.
结论:
- 尾肌瘦质 (ALM) 和肉症与广泛的全身健康结果有显著的关联.
- 这些发现强调了ALM对整体健康状况的广泛影响,并为其重要性提供了流行病学证据.
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