纵向三糖糖-葡萄糖指数和金属相互作用:一个多模型队列,整合了协同和对抗指数
Jinhao Jia1, Yihong Di1, Limeng Xiong1
1School of Public Health, Department of Medical Records and Statistics, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan Ningxia 750004, P.R. China; Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750004, Ningxia, People's Republic of China.
Environmental pollution (Barking, Essex : 1987)
|January 24, 2026
概括
长度金属暴露,包括和,影响中国老年人的胰岛素耐药性 (TyG指数). 这些影响随着时间的推移而变化并相互作用,强调风险评估中的复杂暴露动态.
科学领域:
- 环境健康 环境健康
- 金属毒理学 金属毒理学
- 代谢综合征研究 代谢综合征研究
背景情况:
- 胰岛素抵抗是2型糖尿病的前体,受到环境因素的影响.
- 复杂金属暴露对胰岛素耐药性的长期影响尚不清楚.
- 甘油三-葡萄糖 (TyG) 指数是量化胰岛素耐药性的可靠标记.
研究的目的:
- 研究多种金属暴露对中国老年人队列的TyG指数的综合和相互作用影响.
- 为了确定特定的金属及其相互作用有助于胰岛素抵抗的纵向变化.
- 为了探索金属相关胰岛素抵抗的性别特异性.
主要方法:
- 对2732名中国老年人的前性队列研究,使用ICP-MS进行了基线尿液金属测量.
- 多模型分析包括金属时间相互作用的线性混合效应模型和混合效应的加权量子式总和回归.
- 扩展了线性混合模型,以评估对对的金属-金属-时间相互作用.
主要成果:
- ,,,,和铜等单个金属与TyG指数呈现正相关性,而铁和则呈现相反相关性.
- 随着时间的推移,积极的关联通常会减弱,而与铁的反向关联会加强.
- 重量定量总和回归确定了由和驱动的积极混合效应,铁具有对抗作用.
- 观察到重要的金属×金属×时间相互作用,其中参与了对抗性组合.
- 性别分层分析显示了修改后的关联.
结论:
- 对单个和混合金属的长时间暴露与中国老年人群的胰岛素抵抗有关.
- 金属暴露的时间依赖性和交互性影响对于理解它们对胰岛素抵抗的影响至关重要.
- 这些发现强调了在对代谢性疾病的环境健康风险评估中需要考虑复杂的暴露动态和个体敏感性.
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