基因组流行病学和Bordetella pertussis的进化动态:中国和全球菌株 (2018-2024) 的比较研究 (2018-2024)
Jianguang Cai1, Yanwei Zhang2, Shuang Wu2
1School of Public Health, Southern Medical University, 510515, China; Shenzhen Center for Disease Control and Prevention, 518000, China.
概括
自2018年以来,抗宏胺的Bordetella pertussis (MRBP) MT28系在中国主导了 pertussis,原因是局部抗宏胺的抵抗. 这种演变需要更新抗生素管理和疫苗接种策略.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 百日咳 (百日咳) 的复发是一个全球性的担忧.
- 目前正在出现耐宏菌的波德特拉百日咳 (MRBP) 菌株.
- MT28-ptxP3血统与最近的百日咳疫情有关.
研究的目的:
- 调查MT28-ptxP3 MRBP血统的起源和演变.
- 了解导致百日咳复发的适应性策略.
- 分析导致宏类耐药性的遗传和流行病学因素.
主要方法:
- 综合流行病学数据 (2013-2024) 与632个B. pertussis分离物 (2018-2024) 的基因组分析.
- 使用的多位置变量数组重复分析 (MLVA) 和单核酸多态 (SNP) 遗传学.
- 比较来自美国,日本,奥地利和越南的国际MT28菌株.
主要成果:
- MT28血统从2018年的6.5%大幅增加到2024年的89.4%,实现了克隆的统治地位.
- 遗传学分析追溯了MT28骨干的全球播种到美国 (2018) 和日本/奥地利 (2019).
- 局部固定23SrRNA A2047G宏化物耐药性突变赋予了健身优势,与青少年 (7-15岁) 感染增加相吻合.
结论:
- 2024年中国百日咳的复苏归因于全球传播的MT28血统中的局部类耐药性.
- 这种血统的进化结合了宏类耐药性,高毒性和疫苗逃脱 (prn 缺乏症).
- 迫切需要对全球抗生素管理和疫苗接种战略进行紧急修订,以应对这一威胁.
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