地方废水监测作为荷兰病爆发调查的补充工具:一项概念验证研究
Maja Joosten1, Aart C Dijkstra1, Maarten de Jong2
1Municipal Health Service North- and Eastern Gelderland (GGD Noord- en Oost-Gelderland), Department of Infectious Diseases, Warnsveld, The Netherlands.
概括
当地废水监测有效追踪疹疫情,检测病毒RNA,即使临床通知很低. 这种方法可以提高公共卫生紧急情况期间的局势意识.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 环境监测 环境监测
背景情况:
- 疹疫情的临床报告率很低,需要使用替代的监测方法.
- 评估当地废水监测对病检测的有效性至关重要.
研究的目的:
- 评估使用当地废水监测用于病监测的可行性.
- 为了将废水病毒检测与临床病例报告相关联.
主要方法:
- 在病房,学校和抽水站附近的废水系统中使用被动采样器.
- 使用逆转录-聚合酶链反应 (RT-PCR) 分析废水样本.
- 从全科医生 (GP) 实践中收集了疑似和确诊病例的数据.
主要成果:
- 在确诊病例诊断后,直接在废水中检测到麻疹病毒RNA.
- 废水中的病毒度增加与报告的病例数量相关.
- 污水监测发现污水扩散到邻近的城镇,包括一个没有报告病例的城镇.
结论:
- 这项研究提供了当地基于废水的病监测的第一个概念验证.
- 使用被动采样器进行废水监测可以提高疫情爆发期间的情势意识.
- 建议废水监测和病临床数据之间存在相关性.
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