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喀麦隆主要输血传播病原体的流行病学和安全挑战:系统性审查和元分析

Michel M Yop Kite¹, Brice L Koloko², Sandrine S Beack Bayengue³

¹Center for Expertise and Research in Applied Biology (CEREBA), Douala 3787, Cameroon; Department of Biochemistry, Faculty of Sciences, The University of Douala, Cameroon.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

|January 24, 2026

概括

在喀麦隆,HIV,HBV,HCV和梅毒等输血传染性感染很普遍,影响了15.4%的捐赠. 需要更多的研究来改善血液安全策略.

科学领域:

公共卫生公共卫生
传染性疾病传染性疾病
输血安全输血安全

背景情况:

输血传染病 (TTIs) 对接受血液的人来说构成重大风险.
喀麦隆的TTI的患病率和决定因素仍然不充分理解,这阻碍了有效的血液安全措施.

研究的目的:

系统地审查和对喀麦隆主要TTIs的流行,模式和决定因素进行元分析.
确定输血安全方面的挑战,并提出解决方案.

主要方法:

36项研究的系统审查和元分析 (72个数据集,约105,000个捐赠).
使用随机模型,对HIV,HBV,HCV和T. pallidum感染率的综合估计.
进行了子组,敏感性和偏见分析.

主要成果:

综合的TTI患病率为15.4% (95%CI为12.7-18.2%),根据测试策略和地区存在显著差异.
同时感染发生在1.5%的捐赠中,HBV+HCV是最常见的 (3.4%).
家庭捐赠者显示,艾滋病毒和T. pallidum感染的风险始终更高. 挑战包括诊断不一致和数据缺口.

结论:

在喀麦隆的献血者中存在着大量的HIV,HBV,HCV和T. pallidum感染负担.
高质量的研究对于制定政策和加强血液安全战略至关重要.
解决数据缺口和提高诊断一致性对于更好的输血服务至关重要.

关键词:

输血输血输血输血输血输血输血喀麦隆 - 喀麦隆 - 喀麦隆流行病学流行病学系统性审查系统性审查主要病原体的主要病原体.进行元分析分析.

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