周围PD-1+ T细胞特征预测肝胆道癌症的免疫治疗反应和存活率
Mingjian Piao1, Jiayu Xiao2, Nan Zhang1
1Department of Liver Surgery State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
概括
周围PD-1+ T细胞可以预测肝胆癌的免疫检查点抑制剂 (ICI) 反应. 较高的T细胞基线水平和较低的中性粒细胞与淋巴细胞比率表明接受免疫治疗的患者的生存结果更好.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 免疫检查点抑制剂 (ICI) 在肝胆恶性瘤中表现有前途,但预测生物标志物很少.
- 外围PD-1+ T细胞可能表明T细胞状态,并预测ICI的临床益处.
研究的目的:
- 调查外围PD-1+ T细胞子集作为ICI治疗响应预测生物标志物在晚期肝细胞癌 (HCC) 和胆道癌 (BTC) 中.
主要方法:
- 预期招募99名接受ICI治疗的患者,并采集周围血液进行流细胞计.
- 随机分配到培训 (n=69) 和验证 (n=30) 队列中.
- 使用卡普兰-梅尔的生存分析和通过LASSO回归和名录构造的预测因子识别.
主要成果:
- 响应者比不响应者有明显更长的无进展生存期 (PFS) 和总生存期 (OS).
- 较高的基线CD3+PD-1+T细胞百分比和较低的中性粒细胞与淋巴细胞比率 (NLR) 与反应有关.
- 肝硬化,CD3+PD-1+T细胞百分比和NLR被确定为独立的预测因子 (AUC 0.846培训;0.670验证).
结论:
- 基线和动态PD-1+T细胞概况有效预测肝胆道癌症的ICI反应和存活率.
- 循环PD-1+ T细胞显示出作为个性化免疫疗法策略的非侵入性生物标志物的潜力.
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