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Drug Delivery: Overview01:16

Drug Delivery: Overview

761
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Intelligence01:27

Intelligence

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The term "intelligence" is complex because it refers to both behavior and individuals, and its interpretation varies across cultures. European Americans tend to link intelligence with reasoning and cognitive skills, while in Kenya, it is tied to responsible participation in family and social life. In Uganda, intelligence is seen as the ability to know the right actions and carry them out effectively, while the Iatmul people of Papua New Guinea associate it with the capacity to remember...
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Machines01:19

Machines

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Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. One example of a machine is the cutting plier, which is used to cut wires by applying forces to its handles. When equal and opposite forces are exerted on the handles of the cutting plier, they cause the cutting edges to come together and apply equal and opposite reaction forces on the wire, which are greater than the applied forces.
A free-body diagram of the...
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人工智能和机器学习引导药物输送的优化.

Helena Ros1, Natasha Chan1, Michael T Cook1

  • 1UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

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概括
此摘要是机器生成的。

人工智能 (AI) 和机器学习 (ML) 为优化药物输送系统提供了先进的解决方案. 这些数据驱动的方法加速开发,减少实验,并发现新的配方,以获得更好的治疗结果.

关键词:
人工智能的人工智能是人工智能.贝叶斯优化的贝叶斯优化机器学习 机器学习优化 优化 优化自动驾驶实验室的自动驾驶实验室

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科学领域:

  • 制药科学 制药科学
  • 计算化学计算化学
  • 生物技术是生物技术.

背景情况:

  • 药物输送系统的优化面临着由于复杂性,高维度和多目标要求的挑战.
  • 传统方法与现代药物输送问题作斗争,需要先进的方法.

研究的目的:

  • 审查人工智能 (AI) 和机器学习 (ML) 对药物配方科学的变革性影响.
  • 提供ML引导优化工作流程及其在药物输送中的应用的概述.

主要方法:

  • 探索AI/ML技术,包括代理建模,贝叶斯优化,主动学习和多目标优化.
  • 对各种药物输送方式的应用进行批判性审查.

主要成果:

  • 人工智能和机器学习使得药物输送的数据驱动,自适应和高效的优化策略成为可能.
  • 这些方法加速了配方开发,减少了实验负担,并确定了新的设计空间.

结论:

  • 人工智能和机器学习正在彻底改变合理的药物设计和优化先进的药物输送系统.
  • 未来的方向包括将人工智能集成到制药研发中,从而实现自动驾驶实验室.