复发性尿道感染症状尺度 (RUTISS):对抗生素治疗的反应和临床重要差异最小值
Abigail F Newlands1, Lydia V Tidmarsh1, Melissa Kramer2
1School of Psychology and Clinical Language Sciences, University of Reading, Reading, Berkshire, RG6 7BE, UK.
Urology
|January 24, 2026
概括
复发性尿路感染症状尺度 (RUTISS) 有效地跟踪了复发性尿路感染抗生素治疗期间的症状变化. 确立了6.5分的最小临床重要差异 (MCID),有助于患者护理.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 临床药理学 临床药理学
- 健康 结果 研究 研究 结果
背景情况:
- 经常性泌尿道感染 (UTI) 对妇女的生活质量产生重大影响.
- 经验证的患者报告结果测量 (PROM) 对于评估复发性尿路感染治疗疗效至关重要.
- 复发性尿道感染症状尺度 (RUTISS) 是为了捕捉尿路感染症状经验而开发的.
研究的目的:
- 为了评估RUTISS对复发性尿路感染的妇女抗生素治疗的反应性.
- 确定RUTISS的临床重要差异最小值 (MCID).
主要方法:
- 一项纵向研究涉及108名女性成年人,在40天内患有复发性尿路感染.
- 在基线,抗生素治疗期间 (1,3日) 和治疗后 (7日) 评估RUTISS得分.
- 使用效果大小,与尺度 (PGIC,UTISA) 的相关性以及ROC分析来确定MCID.
主要成果:
- RUTISS对抗生素治疗表现出色的反应,在基线和第3天之间观察到最强的变化.
- 在RUTISS得分和患者全球变化印象 (PGIC) 和尿路感染症状评估 (UTISA) 之间发现了强烈的相关性.
- 确立了6.5分的验证的MCID,表明临床上有意义的改善.
结论:
- RUTISS是一个响应性和验证的PROM,用于评估复发性尿路感染的症状.
- 建立的MCID允许精确解释治疗效果和患者症状变化.
- RUTISS支持临床试验,基于证据的监测,以及改善复发性尿路感染患者的护理.
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