皮肤状细胞癌的基于PDT的组合治疗现状:从分子机制到临床实践
Ziwei Kang1, Guorong Yan1, Guolong Zhang1
1Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China; Institute of Photomedicine, School of Medicine, Tongji University, Shanghai 200443, China.
Biochimica et biophysica acta. Reviews on cancer
|January 24, 2026
概括
光动力学疗法 (PDT) 对表面皮肤状细胞癌 (cSCC) 显示出希望. 组合策略通过增强光敏剂的递送,瘤细胞死亡和抗瘤免疫力,显著提高PDT的疗效.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 照相医疗 (photomedicine) 是一种医学.
背景情况:
- 光动力疗法 (PDT) 是表面皮肤状细胞癌 (cSCC) 的标准治疗方法.
- PDT的局限性包括组织透性差和瘤缺氧,这可能会降低治疗的有效性.
- 目前正在探索组合策略,以克服这些局限性,并改善cSCC中的PDT结果.
研究的目的:
- 审查cSCC的PDT的机制.
- 总结目前对cSCC基于PDT的组合策略的研究.
- 确定未来研究的关键领域,以优化PDT的疗效.
主要方法:
- 对PDT及其对cSCC的组合进行临床和基础科学研究的审查.
- 分析组合疗法所使用的协同作用机制.
- 确定局限性和未来的研究方向.
主要成果:
- 涉及局部药物,全身疗法和物理干预的组合策略显著提高了cSCC中PDT的疗效.
- 协同作用的机制包括改善光敏剂的积累/传递,增强瘤细胞死亡,增强抗瘤免疫力.
- 大多数组合方法与单独使用PDT相比,显示出更好的临床结果.
结论:
- 基于PDT的组合策略提供了一种有希望的方法来改善cSCC的管理.
- 未来的研究应该专注于优化光剂量测量和开发有针对性的光敏剂.
- 在大规模临床试验中对组合方案的验证对于临床转化至关重要.
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