使用Zain-chitosan输送系统制造,表征和结合机制的酸载荷纳米颗粒使用Zain-chitosan输送系统
Caihong Xu1, Xi Chen1, Hong Wang2
1College of Grain Science and Technology, Shenyang Normal University, Shenyang, PR China.
International journal of biological macromolecules
|January 24, 2026
概括
这项研究开发了Zain-chitosan纳米颗粒,以改善酸 (FA) 输送. 优化的系统增强了功能性食品和营养保健品的FA生物可用性和稳定性.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 食品科学 食品科学 食品科学
背景情况:
- 酸 (FA) 具有有价值的生物活性,但其生物可用性和不稳定性较差.
- 现有的FA传递系统在有效性和应用范围方面存在局限性.
研究的目的:
- 设计先进的Zain-chitosan (Zein-CS) 纳米颗粒,用于增强酸 (FA) 输送.
- 通过评估基托桑分子量和Zeen-CS比率来优化纳米粒子配方.
- 评估开发的FA载纳米粒子的物理化学特性,稳定性和体外释放特征.
主要方法:
- 纳米颗粒配方使用Zeen和奇托具有不同的分子量.
- 优化Zain-CS比率以提高封装效率.
- 粒子大小,多分散度指数 (PDI) 和泽塔电位的表征.
- 分子对接以预测Zain-FA-CS复合体内的相互作用.
- 在不同的pH条件下进行体外释放研究 (模拟胃和肠道环境).
主要成果:
- 最佳的Zain-CS配方实现了高封装效率 (~75.11%) 和良好的体稳定性 (颗粒大小~208.8 nm,PDI=0.24,泽塔电位+23.4 mV).
- 分子对接证实了稳定的三元复合体形成,具有显著的结合能量 (-9.38 kcal/mol).
- 在体外研究表明pH取决于释放,在模拟的胃条件下释放低 (≤31.37%) 和在模拟的肠条件下释放高 (≥88.72%在6小时内).
结论:
- 酸纳米颗粒代表了一种有前途的输送系统,可以提高酸的生物可用性和稳定性.
- 开发的系统显示了在功能性食品和营养药应用中有针对性交付的潜力.
- 这种方法可以扩展到改善其他疏水生物活性化合物的输送.
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