具有或没有轻度认知障碍的代谢综合征患者的白质异常:一个扩散张力图像研究
Wen Shao1, TianTian Zhu2, Xiaoxiao Xiong2
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Department of Neurology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China.
Behavioural brain research
|January 24, 2026
概括
具有轻度认知障碍 (MCI) 的代谢综合征 (MetS) 患者比没有认知障碍的患者表现出更严重的白质损伤 (WM). 骨髓膜损伤可能导致MetS的认知衰退.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢综合征 (MetS) 是认知功能障碍和痴呆症的危险因素.
- MetS可以破坏白质 (WM) 微观结构.
- 在有或没有轻度认知障碍 (MCI) 的MetS患者之间,WM完整性可能会有所不同.
研究的目的:
- 使用扩散张力成像 (DTI) 调查有或没有MCI的MetS患者的WM变化.
- 将MCI的MetS患者,正常认知的MetS患者 (MetS-NC) 和健康的对照 (HC) 之间的WM微结构差异进行比较.
主要方法:
- 包括36名MetS-MCI患者,30名MetS-NC患者和36名HC患者.
- 使用基于路径的空间统计 (TBSS) 和兴趣区域 (ROI) 分析DTI数据.
- 评估的分数异构性 (FA),平均扩散性 (MD),轴向扩散性 (λ1) 和半径扩散性 (λ23).
主要成果:
- 与HC相比,MetS-MCI患者显示MD,λ1和λ23的增加.
- 与HC相比,MetS-NC患者的MD和λ1增加.
- 与MetS-NC患者相比,MetS-MCI患者的MD和λ23显著更高.
- 特定的WM区域 (例如,EC.L,IFO.L,UF.R) 显示了与认知衰退,执行功能和记忆缺陷相关的改变DTI指标.
结论:
- 患有MCI的MetS患者比没有认知障碍的患者表现出更严重的WM损伤.
- 骨髓包完整性的损失与MetS患者的认知衰退有关.
- 特定的WM纤维捆绑与MetS患者的独特认知功能有关.
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