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Updated: Jan 26, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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在KRAS驱动的肺癌中,TRAF6通过AKT/线粒体损伤促进铁亡防御

Weibang Yu1, Yiwen Cui2, Sixin Li3

  • 1School of Ocean and Tropical Medicine. Guangdong Medical University, Zhanjiang, Guangdong 524023, China; The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong 524023, China.

Biochemical pharmacology
|January 24, 2026
PubMed
概括

瘤坏死因子受体相关因子6 (TRAF6) 在KRAS突变肺癌中驱动铁. 抑制TRAF6或使用五甲基葡萄糖 (PGG) 触发铁亡,抑制瘤生长.

关键词:
铁性化 (ferroptosis) 是一种克拉斯 (Kras) 是一个国家.肺癌是一种肺癌.线粒体中的线粒体.五甲基葡萄糖 (PGG) 是一种五甲基葡萄糖.在TRAF6中,

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