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Updated: Jan 26, 2026

siRNA Screening to Identify Ubiquitin and Ubiquitin-like System Regulators of Biological Pathways in Cultured Mammalian Cells
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可逆无化调节HSF1阶段分离,以应对蛋白质毒性压力

Yue Zhu1, Jianhua Wang2, Shuhong Tang2

  • 1The Fifth People's Hospital of Dalian, Dalian Medical University, Dalian, China; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.

Life sciences
|January 24, 2026
PubMed
概括

在蛋白质毒性应激过程中,乌比基因化驱动热冲击因子1 (HSF1) 凝结. STUB1促进HSF1相分离,而USP13和ATXN3抑制它,揭示了关键的调节作用.

关键词:
脱基化酶是一种脱基化酶.E3 结合酶的使用在HSF1中,它是HSF1.阶段分离 阶段分离 阶段分离蛋白质毒性压力是保护性毒性的.在Ubiquitination中使用.

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