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Updated: Jan 26, 2026

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
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Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

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自组装的具有GSH/ROS部位响应的多组件前体药物可实现空间时间控制的释放,用于治疗耐药NSCLC

Chaozheng Zhang1, Yao Chen2, Xiaoke Shi3

  • 1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Journal of controlled release : official journal of the Controlled Release Society
|January 24, 2026
PubMed
概括

这项研究开发了一种新型纳米药物PSOTNs,用于克服非小细胞肺癌 (NSCLC) 中的帕克利塔塞尔耐药性. PSOTN结合了三种药物,具有协同作用,增强了对抗耐药瘤的治疗疗效.

关键词:
药物耐药性 药物耐药性 药物耐药性在GSH/ROS的部位响应性.多组分前体药物 多组分前体药物在NSCLCLC中,我们可以看到.这是一种PARP抑制剂.帕克利塔克塞尔 (Paclitaxel) 是一种药物.

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