生物打印带有共生微生物的敷料供氧和抗菌疗法增强糖尿病伤口愈合
Kaifeng Lin1, He Xu2, Hai Liu3
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, College of Biomass Science and Engineering, Sichuan University, Chengdu 610041, Sichuan, China.
一种新的生物活性微生物水凝敷料通过提供氧气和对抗细菌,促进糖尿病伤口愈合. 这种工程生物材料在糖尿病模型中加速组织再生.
科学领域:
- 生物材料工程 生物材料工程
- 再生医学是一种再生医学.
- 微生物学 微生物学
背景情况:
- 糖尿病慢性伤口由于高血糖,炎症和缺氧而缓慢愈合.
- 现有的治疗方法往往无法解决复杂的伤口微环境.
- 微生物共生提供了一个有前途的治疗途径.
研究的目的:
- 为了设计一个3D打印的生物活性微生物水凝 (BMH) 敷料.
- 使用Chlorella zofingiensis和Bacillus subtilis创建一个人工的共生系统.
- 通过调节伤口微环境,促进糖尿病伤口愈合.
主要方法:
- 在凝中嵌入Chlorella zofingiensis和Bacillus subtilis. 在凝中嵌入Methacryloyl.
- 生物活性微生物水凝 (BMH) 敷料的3D打印.
- 在糖尿病老鼠模型中的评估,包括RNA测序.
主要成果:
- 该BMH敷料表现出光合作用自我氧化和抗菌活性.
- 在高血糖症下,BMH促进了纤维细胞迁移和血管生成.
- 在体内研究显示,缺氧和炎症减少,血管化增强和原沉积.
- RNA测序表明免疫调节和皮肤再生通路的升级.
结论:
- 工程 BMH 包裹有效地促进糖尿病慢性伤口愈合.
- 这种多模式的治疗策略解决了伤口缺氧和炎症.
- 该研究提供了关于为再生工程设计生物材料的见解.
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