班希亚百祖天玛可以通过调节脂肪细胞-免疫细胞通信来减轻肥胖症
Weipin Niu1, Denglu Zhang1, Huifei Zhang2
1Central Laboratory, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan 250011, China.
Journal of ethnopharmacology
|January 24, 2026
概括
班希亚百祖天玛 (BBTD) 通过改善脂肪组织炎症来降低肥胖. 这种传统中医药配方抑制炎症细胞透和交流,为肥胖管理提供治疗潜力.
科学领域:
- 整合和补充医学是整合和补充医学.
- 代谢疾病 代谢疾病
- 免疫学 免疫学 免疫学
背景情况:
- 班夏百祖天玛 (Banxia Baizhu Tianma Decoction,简称BBTD) 是一种用于湿综合征的传统中医配方.
- 它的抗肥胖作用,特别是对脂肪组织 (AT) 炎症的作用,需要阐明分子机制.
研究的目的:
- 评估BBTD的抗肥胖作用.
- 研究BBTD对AT炎症作用的分子机制.
主要方法:
- 在使用高脂肪饮食 (HFD) 的小鼠中诱导肥胖.
- 单核RNA测序 (snRNA-seq) 分析了 epididymal 白脂肪组织 (eWAT) 的细胞格局.
- 对比了正常,高肥胖症诱导的肥胖 (模型) 和接受BBTD治疗的组的细胞变化.
主要成果:
- HFD诱导脂肪细胞缩,脂质积累和AT代谢功能障碍.
- 接受BBTD治疗可以逆转HFD引起的变化.
- snRNA-seq揭示HFD增加了炎症因素和AT巨细胞 (ATM),促进了脂肪细胞-巨细胞交叉.
- 通过抑制IL-7R+ LAMs透和细胞相互作用,BBTD减轻了AT炎症.
结论:
- BBTD证明了对肥胖的治疗潜力.
- 通过减少炎症,BBTD可以改善脂肪组织的微环境.
- 通过其对AT的免疫调节作用,BBTD可能为管理肥胖提供了一种新的方法.
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