齐苏粉中的过程-功能-结构关系:传统加工如何保留更活跃的成分并改善治疗结果
Mingkang Zhang1, Hao Li1, Shuo Chen1
1School of Pharmacy Heilongjiang University of Chinese Medicine, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education 150040.
Journal of ethnopharmacology
|January 24, 2026
概括
与其药典对应物 (ZXPP) 相比,传统的Zixue粉末 (ZXTP) 在治疗发烧发作方面表现出更高的疗效. ZXTP表现出更高的活性化合物水平,更快的释放,以及增强的神经保护作用,突出了制备方法的影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 草药是一种草药.
- 神经科学是一个神经科学.
背景情况:
- 齐粉 (ZXTP) 是一种用于发烧性的传统草药.
- 传统和药典制备方法 (ZXPP) 之间存在差异.
- 这些制剂差异对疗效的影响尚不清楚.
研究的目的:
- 为了系统地比较ZXTP和ZXPP.
- 评估化学含量,体外释放和治疗功效的差异.
- 调查观察到的变化背后的原因.
主要方法:
- 粉末属性的比较分析.
- 用HPLC进行指纹和化学分析,用于化学分析.
- 在体外释放研究和发烧性发作的老鼠模型.
- 对于分子标 (TNF-α,GluA1,CaM) 和微观结构的SEM,西式涂抹.
主要成果:
- ZXTP在粉末特性和更高水平的关键成分中显示出显著的差异,包括阿加托特.
- 对于几个成分,ZXTP在体外释放率更快.
- 这两种药物都显示出抗作用,但ZXTP提供了优越的控制和神经保护,更好地保护海马神经元.
- 在ZXTP和ZXPP之间观察到明显的微观结构特征.
结论:
- 与药典制剂 (ZXPP) 相比,传统的Zixue粉末 (ZXTP) 显示出增强的治疗效果.
- 制备方法显著影响Zixue粉末的物理化学和药理特性.
- ZXTP的卓越疗效与更高的成分水平,更快的释放和独特的微观结构特征有关.
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