免疫治疗在局部先进的头和部状细胞癌:目前的状况和未来的前景
Bahadır Köylü1, Fatih Selçukbiricik1, Sercan Aksoy2
1Koç University School of Medicine, Department of Internal Medicine, Division of Medical Oncology, 34010, Istanbul, Türkiye.
Critical reviews in oncology/hematology
|January 24, 2026
概括
免疫检查点抑制剂对局部发达的头部和部状细胞癌有前途,改善可切除病例的生存率. 对于不可切除的疾病需要进一步的研究,并探索新的免疫疗法.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 头部和部癌症 头部和部癌症
背景情况:
- 头部和部状细胞癌 (HNSCC) 是一个主要的全球健康问题,通常在本地晚期诊断出来.
- 多模式治疗是局部发达HNSCC的标准.
- 免疫检查点抑制剂 (ICI) 已改善了复发性/转移性HNSCC的治疗结果,但它们在局部晚期疾病中的作用仍在发展.
研究的目的:
- 综合当前关于免疫治疗局部发达HNSCC的证据.
- 探索未来的方向,以免疫疗法管理局部先进的HNSCC.
主要方法:
- 最近的第三阶段试验 (KEYNOTE-689,NIVOPOSTOP) 在可切除局部先进的HNSCC.中进行了审查.
- 对ICI在不可切割的局部先进HNSCC中的疗效数据的分析.
- 探索新兴的免疫疗法.
主要成果:
- 术后和辅助免疫疗法在可切除局部先进的HNSCC.中证明了无事件和无疾病生存率的改善.
- 在不可切除的局部晚期HNSCC中ICI疗效显示不一致的结果,突出了对患者选择和生物标志物的需要.
- 新型免疫疗法,如双特异性抗体和CAR T细胞疗法,提供了未来的潜力.
结论:
- 免疫疗法融入可切除局部先进HNSCC的治疗策略得到了最近的试验数据的支持.
- 优化ICI时间,序列和患者选择对于不可切除的局部高级HNSCC至关重要.
- 新兴的免疫疗法代表了先进的HNSCC管理的一个有希望的前沿.
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