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Prostatic Adenocarcinoma 在膀瘤的尿道切除中鉴定出前列腺腺癌:一个临床病理学系列的诊断相关的潜在陷
Douglas Jian-Xian Wu1, Richard Pacheco1, Emily Chan1
1Stanford Medical Center, Stanford, CA.
Human pathology
|January 24, 2026
概括
前列腺腺癌 (PCA) 可以在膀瘤切除上模仿泌尿器癌 (UC). 仔细审查形态学和临床病史至关重要,以避免误诊并确保准确的患者管理.
科学领域:
- 尿路病理学 尿路病理学
- 手术病理学手术病理学
- 在瘤学瘤学.
背景情况:
- 前列腺腺癌 (PCA) 在膀瘤切除中越来越多地被发现.
- 将PCA误诊为尿路细胞癌 (UC) 有显著的临床影响.
- 准确的区分对于适当的患者管理和治疗至关重要.
研究的目的:
- 调查通过尿道膀瘤切除 (TURBT) 发现的PCA的临床病理特征.
- 确定潜在的诊断挑战和有帮助的特征,以区分PCA从UC在TURBT标本.
- 评估泌尿科医生和病理学家之间的临床病史和PCA怀疑的沟通.
主要方法:
- 54个含有PCA的TURBT标本的回顾性分析,来自高等学术医院 (2003-2025年).
- 审查患者病史,样本征集细节,以及他的病理特征.
- 囊镜检测结果和瘤位置与诊断考虑的相关性.
主要成果:
- 大多数PCA瘤位于膀部或膀底部 (72%).
- 共同的形态特征包括伪毛囊/毛囊样生长 (46%) 和固体/嵌套结构 (70%).
- 大多数情况下,核特征如均性和突出的核细胞被发现,可能有助于与UC的差异化.
结论:
- PCA可以呈现模仿 TURBT 上 UC 的特征,特别是具有伪毛囊/毛囊样生长和坚固的架构.
- 核形态,包括突出的核细胞,可以是关键的区分特征.
- 建议在怀疑高时进行彻底的图表审查和明智地使用免疫组织化学来确定确诊.
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