与精神分裂症谱系障碍相比,在其他特定的精神分裂症谱系和其他精神病障碍中改变了基于听觉种子的功能连接性
Woo-Sung Kim1, Soyolsaikhan Odkhuu1, Eun-Jin Jeon2
1Department of Psychiatry, Jeonbuk National University, Medical School, Jeonju, Korea.
Schizophrenia (Heidelberg, Germany)
|January 24, 2026
概括
这项研究使用神经成像来发现患有其他特定精神分裂症谱系和其他精神病障碍 (OSSO) 和精神分裂症谱系障碍 (SSD) 的患者之间大脑连接的差异. 研究结果表明,OSSO可能是一种独特的综合症,具有独特的神经连接体.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 精神分裂症谱系障碍 (SSD) 已得到充分研究,但其他特定的精神分裂症谱系和其他精神病障碍 (OSSO) 仍然不太了解.
- 很少有神经成像研究探索了神经支柱,使OSSO与SSD有所区别.
研究的目的:
- 识别明显的功能连接 (FC) 特性,使OSSO患者与SSD患者和健康对照者 (HC) 有区别.
- 探索OSSO和SSD组中改变的FC和特定症状之间的关系.
主要方法:
- 休息状态功能磁共振成像 (rs-fMRI) 用于88名OSSO患者,81名SSD患者和85名HC患者,根据年龄,性别和教育情况进行了匹配.
- 进行了基于种子的审计性FC分析,包括种子对voxel,种子对感兴趣区域 (ROI) 和基于网络的连接性分析.
- 研究了改变FC和临床症状 (幻觉,妄想,负面症状) 之间的相关性.
主要成果:
- 与OSSO组相比,SSD组表现出较高的状回环 (STG) 和前之间,以及极皮质 (TP) 和前之间的连接性.
- 与HC相比,OSSO和SSD两组都显示出基于听觉种子的整体低连接性和基于中圈的超连接性.
- 特定的FC模式与症状严重程度相关:在OSSO中,幻觉严重程度与insula-putamen连接相关;在SSD中,幻觉严重程度与STG-Heschl环状和TP-insula连接相关.
结论:
- 在OSSO和SSD之间存在明显的功能连接差异,支持将OSSO归类为单独的临床综合征.
- 这些发现突出了OSSO和SSD的独特神经连接体.
- 未来的研究可以调查针对这些改变的连接模式的干预措施,以潜在地防止从OSSO向SSD的进展.
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