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Updated: Jan 26, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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BiG-SCAPE 2.0和BiG-SLiCE 2.0:可扩展,准确和互动的代谢基因集群的序列聚类

Arjan Draisma1, Catarina Loureiro1, Nico L L Louwen1

  • 1Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708PB, Wageningen, The Netherlands.

Nature communications
|January 24, 2026
PubMed
概括

新的生物信息学工具BiG-SCAPE 2.0和BiG-SLiCE 2.0增强了微生物代谢基因集群的分析. 这些工具提高了发现新型自然产品和了解微生物组的可扩展性和准确性.

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Cluster Sampling Method01:20

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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