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肠道微生物群代谢物对结直肠癌的化疗效果产生积极影响
Sara Gomes1,2,3,4,5, Sara Granja6,7, Luana A Osório8
1CBMA - Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, 4710-054, Braga, Portugal.
Cell biology and toxicology
|January 24, 2026
概括
短链脂肪酸 (SCFA) 增强了5-Fluorouracil (5-FU) 用于结直肠癌 (CRC) 的化疗. 这种组合抑制了CRC的生长,改善了治疗结果,提供了一个有前途的辅助策略.
科学领域:
- 在瘤学瘤学.
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 是癌症死亡的主要原因,通常是晚期诊断的.
- 目前的治疗方法,如5-Fluorouracil (5-FU) 面临挑战,包括耐药性和毒性.
- 来自肠道微生物群的短链脂肪酸 (SCFA) 显示出作为抗癌剂的潜力.
研究的目的:
- 调查SCFA是否可以增强5-FU对CRC的疗效.
- 在各种临床前模型中评估SCFA和5-FU联合治疗.
- 确定SCFA对CRC细胞行为和瘤生长的影响.
主要方法:
- 利用2D细胞培养和3D模型进行体外分析.
- 在体内评估中使用胆膜 (CAM) 试验.
- 评估SCFA对CRC细胞生长,增殖,存活和迁移的影响.
主要成果:
- 在不同模型中,SCFA增强了低剂量5-FU的抗瘤作用.
- 联合治疗显著抑制了CRC细胞的生长,增殖,存活和迁移.
- 在CAM试验中,结合SCFA和5-FU治疗时,瘤大小显著减少.
结论:
- 从生理上相关的SCFA组合可以改善CRC中的5-FU治疗指数.
- 针对微生物群的辅助剂策略可以优化CRC化疗.
- 这些发现支持制定策略,以减少CRC治疗毒性并改善患者的治疗结果.
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