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阿里碳化合物受体的激活改变了流感A病毒感染期间的紧急血液形成
Kristina N Fenner1, Alicia M Healey2, Anthony M Franchini1
1Department of Environmental Medicine, University of Rochester, Rochester, NY.
概括
阿里碳水化合物受体 (AHR) 的激活会根据连接体对紧急血液形成产生不同的影响. 在流感感染期间,AHR信号影响免疫细胞的产生,影响血液和肺中的单细胞水平.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 毒理学 毒理学 毒理学
背景情况:
- 造血干细胞和原始细胞 (HSPC) 通过造血来驱动血液和免疫细胞的产生.
- 紧急血液形成是HSPC对感染期间免疫细胞需求增加的快速反应.
- 已知阿里碳化合物受体 (AHR) 信号调节免疫反应和稳定状态血液形成.
研究的目的:
- 调查AHR激活在流感A病毒感染期间对HSPC和原生细胞的影响.
- 为了比较两个不同的AHR配体TCDD和ITE对紧急血液形成的影响.
- 为了确定AHR在感染期间对造血的作用是否取决于其在造血细胞内的表达.
主要方法:
- 小鼠感染了流感A病毒,并用AHR配体TCDD或ITE进行治疗.
- 流细胞计用于分析骨髓,血液和肺部中HSPC和原始细胞的比例.
- 使用Vav1CreAhrfxfx小鼠来评估AHR在造血细胞中的作用.
主要成果:
- 由TCDD激活AHR,但不是ITE,促进了HSPC的骨髓偏差.
- 无论是TCDD治疗还是ITE治疗,都能降低肺内单细胞的频率.
- 在使用Vav1CreAhrfxfx小鼠的血液细胞中证实了依赖于AHR的效应.
结论:
- 在紧急血液形成过程中,AHR配体对HSPC产生明显的影响.
- 在病毒感染期间,AHR信号在调节血液和肺中的单细胞种群中发挥作用.
- 这些发现强调了环境暴露对感染期间免疫反应的影响.
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