长期暴露于低水平的草甘和金属会导致功能障碍
Ilaria R Merutka1, Kerry M Ettinger1, Melissa Chernick1
1Nicholas School of the Environment, Duke University, Durham, NC, United States.
概括
长期暴露于饮用水中的草甘和金属会随着时间的推移损害功能. 同时暴露会恶化结果,强调环境污染物是慢性病 (CKD) 的关键驱动因素.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 毒理学 毒理学 毒理学
背景情况:
- 慢性病 (CKD) 影响全球数百万人,环境污染物越来越多.
- 长期,低水平暴露于农药和金属混合物的机制仍然不太清楚.
- 以前的研究将饮用水中的草甘和金属与脏发育障碍联系起来.
研究的目的:
- 调查慢性低水平暴露于草甘,金属及其组合对功能和结构的影响.
- 用成年斑马鱼作为模型来阐明环境病的机制.
- 为了确定特定的脏目标和受这些暴露影响的细胞过程.
主要方法:
- 成年斑马鱼在10天和60天内暴露在草甘 (10ppb),金属混合物 (Cd,As,Pb,V) 或两者之间.
- 通过低分子量蛋白尿,组织病理学和代谢学来评估功能和结构.
- 评估线粒体的健康状况,包括功能,拷贝数和线粒体衰变.
主要成果:
- 长期暴露于草甘和金属导致明显但重叠的毒性,包括管状损伤和代谢改变.
- 共同暴露导致了最严重的损伤,特别是影响了线粒体β氧化,呼吸和线粒细胞衰竭.
- 富含线粒体的近接管被确定为草甘金属暴露的关键目标.
结论:
- 草甘和金属,在饮用水中发现的水平,在长期暴露时损害功能.
- 与单个化学物质暴露相比,联合暴露会加剧损伤.
- 这项研究提供了对环境污染物对CKD风险和脏健康的贡献的机制性见解.
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