严重疾病期间肝功能异常
Philippe Meersseman1, Alexander Wilmer1, Lies Langouche2
1Medical Intensive Care Unit, Department of General Internal Medicine, University Hospital Leuven.
Current opinion in critical care
|January 25, 2026
概括
肝功能障碍影响到40%的ICU患者,增加死亡率. 通过动态肝功能测试及了解急性至慢性肝衰竭 (ACLF) 的早期检测对于更好的结果至关重要.
科学领域:
- 关键护理医学 关键护理医学
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 肝功能障碍在重症患者 (20-40%) 中很常见,并且与更糟糕的结果有关.
- 异常的肝功能测试 (LFTs) 可能源于败血症,药物毒性,缺氧或先前存在的肝病.
- 肝功能障碍可能是ICU入院的主要原因或在住院期间发展.
研究的目的:
- 审查了解严重病患者肝功能障碍的最新进展.
- 强调急性至慢性肝衰竭 (ACLF) 的诊断和治疗.
- 突出动态肝功能测试对于早期检测和预后的重要性.
主要方法:
- 关于严重疾病中肝功能障碍的最新文献的综述.
- 专注于动态肝功能测试 (例如,氨酸绿色清除).
- 在急性至慢性肝衰竭 (ACLF) 中探索不断发展的概念.
主要成果:
- 动态肝功能测试有助于早期检测和预后.
- 认可ACLF是一种需要及时干预的全身性疾病.
- 了解肝功能障碍和多器官衰竭之间的联系是关键.
结论:
- 最近的进展改善了对肝功能障碍机制,诊断和管理的理解.
- 特别强调的是急性至慢性肝衰竭 (ACLF).
- 改善的管理策略对于这种患者群体至关重要.
相关概念视频
Classification of Illness
8.6K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
8.6K
Abnormal Proliferation
5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Factors Affecting Illness
5.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
5.2K
Concepts of Health and Illness
17.6K
Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
17.6K
Dimensions of Health and Illness
10.8K
The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
10.8K
Critical Region, Critical Values and Significance Level
13.3K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.3K


