全球流行病学和成年人类类类型流感病毒的疾病负担:系统性审查
Oliver Martyn1, Clemens Vlasich1, Veronika Khariv2
1Sanofi Vaccines, Lyon, France.
Reviews in medical virology
|January 25, 2026
概括
类似流感病毒 (PIV) 感染对成年人造成的健康风险被低估了,特别是那些免疫力受损或慢性疾病的人. 需要更多的研究来了解其全球流行程度和经济影响.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 偏流感病毒 (PIV) 是已知的导致儿童和免疫受损的成年人呼吸系统疾病的原因.
- 关于PIV流行病学和一般成年人群中的疾病负担的数据有限.
研究的目的:
- 审查全球流行病学数据和成人PIV的疾病负担,包括高风险群体.
- 为了确定PIV研究中现有的数据缺口.
主要方法:
- 2014-2023年PubMed.中的PRISMA系统审查出版物.
- 包括的研究报告了成人 (≥18岁) 和高风险患者的PIV患病率和疾病负担 (住院治疗,死亡率).
主要成果:
- 审查了65项研究,数据偏向亚洲,欧洲和北美.
- 在一般成年人群中,PIV的总体流行率在0-15.2% (中位数为2%) 之间,PIV3是最常见的.
- 患病率在高风险成年人 (高达41%) 和≥65.5的人群中更高. 高风险群体的死亡率在2%-40%之间.
结论:
- PIV感染是一个被低估的负担,具有显著的发病率和死亡率风险,特别是在高风险人群中.
- 关于PIV在一般成年人群中的全球流行率和经济影响,仍然存在大量的知识差距.
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