斑马鱼胚胎中碳化物Ti3C2Tx (MXene) 纳米片的发育毒性和心脏毒性
Zihao Fu1,2, Yifan Bu2,3, Qianqian Xiang4
1School of Ecology and Environmental Sciences, Yunnan University, Kunming, 650091People's Republic of China.
Environmental toxicology and chemistry
|January 25, 2026
概括
二维纳米材料MXene Ti3C2Tx在斑马鱼胚胎中表现出发育和心脏毒性. 较大的MXene Ti3C2Tx片更有毒,破坏了关键的代谢途径,需要进行生物安全评估.
科学领域:
- 环境毒理学环境毒理学
- 纳米材料的安全性
- 水生生物健康 水生生物健康
背景情况:
- 二维纳米材料MXene Ti3C2Tx用于生物医学和水处理.
- 对于MXene Ti3C2Tx在水生生物中的生物毒性作用和机制尚不清楚.
研究的目的:
- 研究斑马鱼胚胎中MXene Ti3C2Tx大直径 (Ti3C2Tx-LD) 和Ti3C2Tx小直径 (Ti3C2Tx-SD) 的发育毒性.
- 使用代谢学和传统方法澄清潜在的毒理机制.
主要方法:
- 在暴露于Ti3C2Tx-LD和Ti3C2Tx-SD的斑马鱼胚胎上应用非向代谢学技术.
- 传统的毒理学评估包括中位数致命度 (LC50) 的确定.
- 评估发育异常,反应性氧物种 (ROS) 生产,亡和心率.
主要成果:
- Ti3C2Tx-LD和Ti3C2Tx-SD的LC50值分别为35.09和50.33毫克/升,较大的板块更有毒.
- 两种Ti3C2Tx大小都诱导了发育问题:化延迟,ROS增加,心周胀,亡和心率降低.
- 代谢学发现了不同的破坏途径:Ti3C2Tx-LD影响了甘油脂和甘油脂的代谢,而Ti3C2Tx-SD影响了氨酸生物合成.
结论:
- MXene Ti3C2Tx在斑马鱼胚胎中显示出显著的发育毒性和心脏毒性.
- 叶片大小影响MXene Ti3C2Tx的毒性,较大的颗粒带来更大的风险.
- 在MXene Ti3C2Tx的广泛工业应用之前,全面的生物安全和环境风险评估至关重要.
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