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Updated: Jan 27, 2026

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与dsDNA的二分化依赖的凝状凝结是人类cGAS激活的基础

Jacob Lueck1, Alexander Strom1, Stephanie Martinez Torres2

  • 1Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Cell reports
|January 25, 2026
PubMed
概括

循环GMP-AMP (cGAMP) 合成酶 (cGAS) 与双链DNA (dsDNA) 形成凝状凝缩物,增强其功能. 这些dDNA激活的cGAS凝通过控制微环境来保护DNA并调节酶活性.

关键词:
CP:细胞生物学 细胞生物学CP:免疫学 免疫学cGAS 是一个气体.凝结剂是一种凝结剂.凝凝是一种凝.具有天生的免疫力.阶段分离的阶段分离.阶段过渡 阶段过渡

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