胎儿大脑扩散权重成像和产前骨髓瘤修复后的产后神经发育结果之间的关联
R Corroenne1, T A G M Huisman2, W E Whitehead3
1Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
概括
胎儿大脑区域的更高的产前明显扩散系数 (ADC) 值表明,在骨髓瘤 (MMC) 修复后,婴儿的神经发育障碍 (NDI). 这一发现有助于在危险儿童中早期识别和管理NDI.
科学领域:
- 神经成像是一种神经成像.
- 发育儿科 发育儿科
- 胎儿外科手术 胎儿外科
背景情况:
- 骨髓瘤结核 (MMC) 与影响神经发育的大脑微观结构变化有关.
- 扩散加权成像 (DWI) 和明显扩散系数 (ADC) 值为胎儿大脑微观结构评估提供客观指标.
研究的目的:
- 用MRI-DWI比较产前大脑ADC值,用于婴儿与产前修复的MMC之间,这些婴儿在≥18个月大时实现了正常与神经发育受损的结果.
主要方法:
- 对50名接受产前MMC修复的儿童进行了回顾性分析.
- 胎儿大脑MRI-DWI在手术后6周进行.
- 在≥18个月时使用卡普特尺度和DP-3测试进行神经发育评估.
主要成果:
- 在大多数大脑区域观察到更高的胎儿ADC值,这些婴儿后来在解决问题,认知和沟通技巧方面被诊断出神经发育障碍 (NDI).
- 在额叶,叶,叶和叶,基底和小脑半球中发现了ADC值的显著差异.
结论:
- 在MMC修复6周后,子宫内ADC值升高与晚期神经发育障碍相关.
- 这些发现支持在产前MMC修复后面面临NDI风险的儿童的早期鉴定和管理策略.
相关概念视频
Diffusion
217.3K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
217.3K
Diffusion
6.3K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
6.3K
Mismatch Repair
43.6K
Overview
43.6K
Overview of DNA Repair
33.5K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Chemically...
33.5K
Weighted Mean
6.2K
While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others.
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
6.2K
Base Excision Repair
26.2K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
The first step of...
26.2K


