外源树突细胞衍生的外体细胞通过IDO1-Kyn-AhR轴促进Treg分化,并改善心肌梗塞后的心脏功能

Yiran Qin1, Youming Zhang2, Mingxuan Li3

  • 1Department of Cardiology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China.

PubMed
概括

树突细胞衍生外体 (DEXs) 通过增强调控性T细胞 (Treg) 分化,促进心肌梗塞 (MI) 后的心脏修复. 这一过程涉及IDO1-Kyn-AhR通路,为心脏修复提供了潜在的治疗策略.

相关概念视频

The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.7K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
65.8K
Derivatives of the Trigonometric Functions01:26

Derivatives of the Trigonometric Functions

The motion of a Ferris wheel rotating at a constant speed provides an intuitive model for understanding trigonometric functions and their derivatives. As a rider moves along the circular path, the vertical height above the ground changes smoothly and periodically over time. This vertical motion can be accurately represented by a sine function, reflecting the repeating pattern of ascent and descent inherent to circular motion.Height and Rate of ChangeIf the rider’s height is modeled by a...
115
Derivatives of Logarithmic Functions01:22

Derivatives of Logarithmic Functions

Logarithmic and Exponential RelationshipA logarithmic function is the inverse of an exponential function. If y = logb x then, it can be rewritten as by = x. This relationship allows for implicit differentiation, making logarithmic functions useful in calculus. Logarithmic scales are widely used to represent data that span multiple orders of magnitude, such as earthquake magnitudes (Richter scale) and sound intensity (decibels).Differentiation of Logarithmic FunctionsTo differentiate y = logb x,...
72
Derivatives of Simple Functions01:27

Derivatives of Simple Functions

Derivatives quantify the rate of change of a function and can be interpreted geometrically as the slope of a straight line or the slope of a tangent line to a curve at a given point. In the context of a roller coaster, the derivative of the function describing the track’s horizontal position provides a mathematical description of how steep the path is at any location along the ride.Constant and Linear PathsA horizontal segment of a roller coaster can be modeled by a constant function,...
125
Second Derivatives of Implicit Functions01:29

Second Derivatives of Implicit Functions

Elliptical arches are fundamental in architectural and structural engineering, offering aesthetic appeal and structural efficiency. The shape of an elliptical arch follows a constrained geometric relationship where the height and horizontal position are implicitly related. This means that the height y cannot be explicitly expressed as a function of the horizontal position x, necessitating implicit differentiation for slope and curvature analysis.The equation of an ellipse centered at the origin...
64