在大鼠中,β-固醇通过ADAM-17/ACE2/Ang 1-7/MasR轴调节减轻了胺素诱导的毒性

Mohamed Gamal El-Din Ewees1, Lobna A Abdelzaher2, Ehab A M El-Shoura3

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, Almaaqal University, 61014 Basrah, Iraq.

PubMed
概括

贝塔-固醇 (BSST) 通过恢复关键信号通路和减少氧化应激,有效地保护对抗 gentamicin 诱导的损伤. 这种植物醇在氨基糖化物治疗期间显示出作为支持性治疗的前景.

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