莱卡尼马布在两年的时间内:来自区域专科医疗中心的关键见解
Lisa B E Shields1, Hust Hannah1, Gregory E Cooper1
1Norton Neuroscience Institute, Norton Healthcare, Louisville, KY 40202 USA.
The journal of prevention of Alzheimer's disease
|January 25, 2026
概括
对阿尔茨海默病的莱卡内马布治疗显示了与粉样蛋白相关的成像异常 (ARIA) 的显著发病率,特别是在APOE ε4同卵性患者中. 密切监测对于 ε4 运营商来说至关重要,以管理潜在的并发症.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 莱卡内马布 (Leqembi®) 是一种抗粉样类单克隆抗体,用于治疗轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 引起的轻度痴呆症.
- 评估粉样蛋白相关成像异常 (ARIA) 和其他不良事件的发生率对于lecanemab的临床应用至关重要.
研究的目的:
- 评估接受lecanemab的患者中ARIA和其他不良事件的发生率.
- 确定与ARIA发展相关的风险因素,如APOE ε4基因型和基线微型血液.
主要方法:
- 在两年内对187名接受lecanemab治疗的患者进行了回顾性观察性研究.
- 对监控大脑MRI进行分析,以检测ARIA (ARIA-H和ARIA-E).
- ARIA发病率与患者人口统计,APOE ε4状态和基线微型血液存在的相关性.
主要成果:
- 22.3%的患者患有ARIA,APOE ε4同卵性个体的发病率更高 (p=0.002).
- 在第五次输液和第十四次输液之前,ARIA最常被检测到.
- 与输液相关的不良事件发生在32.1%的患者中,通常是轻度头痛,通过输液前药物减少.
结论:
- ARIA是lecanemab治疗的一个重要问题,特别是在APOE ε4同卵性患者中.
- 建议对患者,特别是e4载体患者进行密切监测,以检测和管理潜在的并发症.
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